HEMOSORBENTS ON THE BASE OF FULLERENES

One of the most widespread diseases of our time is the atherosclerotic defeat of the cordial-vascular system. Its such complications as ishemic defeats of aorta, heart, brain, kidneys and some other organs are the leading causes of mortality and disablement in developed countries. As the basic reason of the development of atherosclerosis various forms is considered the violation of functional activity, decrease or absence of the appropriate receptors for lipoproteids of low density on cell membranes.

In today's world there is lack of sorbents, having high absorbing capacity and high selectivity of adsorption of of low density atherogen lipoproteids, causing atherosclerotic damage of the walls of aorta and vessels. Even for such radical method of treatment, as surgical interference for coronary shunting, the absence of means slowing the development of atherosclerosis reduces the necessity of repeated operation 5 years later.

Thanks to the fundamental researches being fulfilled in the framework of the programme of the Ministry of Science and Technologies of the Russian Federation "Fullerenes and atomic clusters" during the last several years a real possibility was fond for creating the unique plasmosorbent having no analogues in world for the blood plasma correction in accordance with the lipoproteids of low density. The final goal of the work is to organize technological production, medical certification and clinical tests of a new sorbent for treatment and prevention of atherosclerosis.

It is supposed that in clinic of atherosclerosis it will be used in the form of sorbent columns similar to those applied for hemodialise incase of kidney incompetence and, hopefully, in the form of preparations for internal use, similarly to the well-known activated coal.

The discovered phenomena of selective sorbtion of the fullerenes preparation to of low density lypoproteids lies in the base of this method. The mechanism of this phenomena is connected with the specificity of quantum-chemical interactions of the fullerene C60 with fibers of the blood plasma. The investigation of this mechanism, doubtlessly, represents the fundamental interest which required the realization of large volume of theoretical calculations, computer modelling and physical-chemical experiments.

The St.-Petersburg scientists (Foundation for Intellectual Collaboration) obtained the application for "Sorbent for deleting atherogene lipoproteids from the blood and the method of its deriving".

Leader of the Project:

Valeriy M. Sedov Prof., Professor,

Head of the Department and Director of the faculty surgery clinic of the St.-Petersburg State Medical Institute named after Academician Pavlov, leading research fellow of the Center of Fullerenes and Nanostructures,